WeightControl.com Interview with: Reed Thomas BS and Dr. Kong Y. Chen PhD Director, Human Energy & Body Weight Regulation Core NIH
WeightControl.com: What is the background for this study?
Response: Over the last century, many studies have looked at the thermoregulation of both arctic and tropical animals; however, far fewer have rigorously measured variations in human thermal physiology, and even less have compared women and men. This study is a part of our ongoing efforts to fill that gap.
These patterns such as the Mediterranean diet, DASH diet, vegetarian diet, or other versions of healthy diets can be adapted to meet individual health needs, food preferences, and cultural traditions.
WeightControl.com Interview with: Frank B. Hu, MD, PhD Professor and Chair Department of Nutrition Harvard T.H. Chan School of Public Health
WeightControl.com: What is the background for this study? What are the main findings?
Response: The current Dietary Guidelines for Americans (DGAs) recommend multiple healthy eating patterns. However, few studies have evaluated whether greater adherence to the DGAs-recommended dietary patterns is associated with long-term risk of total and cause-specific mortality. The researchers used health data collected over 36 years from 75,230 women participating in the Nurses’ Health Study and 44,085 men in the Health Professionals Follow-up Study. All participants were free of cardiovascular disease or cancer at the beginning of the study and completed dietary questionnaires every four years.
Their information was scored based on each of the four dietary pattern indexes (Healthy Eating Index 2015, Alternate Mediterranean Diet, Healthful Plant-based Diet Index, and Alternate Healthy Eating Index). All share key components including whole grains, fruits, vegetables, nuts, and legumes, although other components differ across different eating patterns.
Older individuals with a weight loss of 5-10% had a higher risk of all-cause mortality: 33% for men and 26% for women.
WeightControl.com Interview with: Dr Monira Hussain MBBS, MPH, PhD Senior Research Fellow & ECF Clinical Research Australian Fellow Public Health and Preventive Medicine Monash University Melbourne Australia
WeightControl.com: What is the background for this study?
Response: The impact of weight changes on healthy older adults is not fully understood, and the association between weight loss and cause-specific mortality needs to be explored using more reliable methods.
Patients were able to stay away from food for a longer time. For some of the patients that was really changing their lives. They are back to normal and not obsessed with food all the time.
WeightControl.com Interview with: Dr. Christian Roth, MD Seattle Children’s Research Institute and Division of Endocrinology Department of Pediatrics University of Washington
WeightControl.com: What is the background for this study? Would you briefly explain what is meant by Hypothalamic Obesity?
Response: Hypothalamic obesity is a different entity of obesity that is rare and very difficult to treat. It is an acquired form of obesity due to injury to the hypothalamus because of a brain tumor and/or its treatment. This causes an abrupt change in body weight regulation because tissues that are important for energy homeostasis are partially or completely removed.
Typically, these patients can’t control their appetite and within a very short time after surgery they gain weight quickly. Their energy expenditure is also very low. So even if they cut down on calorie intake, they are typically not able to lose weight.
females lost more weight than males with similar exposures to liraglutide, suggesting that body size may not be the only factor.
WeightControl.com Interview with: A/Prof Samantha L Hocking | Associate Professor Diabetes NSW & ACT Sydney School of Medicine (Central Clinical School) Charles Perkins Centre Faculty of Medicine and Health President National Association of Clinical Obesity Services
WeightControl.com: What is the background for this study?
Response: Numerous studies have shown that the mean response to a weight loss intervention hides significant individual variation. There are biological and physiological differences between males and females so gender is a potential predictor of weight loss outcomes.
Women with lower body fat, and in fitness attire, are more likely to post images of themselves on Instagram than women of higher adiposity.
WeightControl.com Interview with: Dr Megan Gow NHMRC Early Career Fellow Research Dietitian and Senior Lecturer The University of Sydney Children’s Hospital Westmead Clinical School Adjunct Senior Lecturer, Women’s and Children’s Health, UNSW Honorary Research Associate, Women’s and Children’s Health, St George Hospital
WeightControl.com: What is the background for this study?
Response: Research has already established that Instagram use is associated with negative impacts on mood and body satisfaction in young women. However, Instagram is highly accessed by women of reproductive age. We assessed 600 images tagged with #postpartumbody systematically captured from Instagram and coded them using a predefined framework.
Exercise is optimal for long-term weight control and prevention of type 2 diabetes when compared with low-calorie diet, low-calorie diet & exercise, fasting, commercial weight loss program, and diet pills.
WeightControl.com Interview with: Dr. Keyi Si, PhD Department of Nutrition Harvard T.H. Chan School of Public Health
WeightControl.com: What is the background for this study?
Response: Weight control is one of the primary and effective strategies for the prevention and management of obesity and related chronic diseases. However, long-term weight change and risks of developing type 2 diabetes following various weight loss strategies are understudied, especially among originally lean individuals.
We know that many people living with obesity do not want to attend health care appointments after a perceived “failure” of a weight loss intervention
WeightControl.com Interview with: Prof Jennifer Logue Associate Dean (Research) Faculty of Health and Medicine Lancaster University Deputy Clinical Director | NIHR CRN North West Coast Professor of Metabolic Medicine | Lancaster University Hon Consultant in Metabolic Medicine Blackpool Victoria Hospital
WeightControl.com: What is the background for this study?
Response: Currently, many providers may offer more intensive therapies to every patient as they don’t believe behavioural programmes are effective, when they are for many people. Other providers leave patients struggling in a behavioural programme and they will disengage, reinforcing self-stigma.
For our study, the time window in which participants were allowed to eat was delibarately set to daytime, with the last meal being ingested at 6 PM the latest. We did this so that the time-window fits in the natural, internal day-night rhythm of humans.
WeightControl.com Interview with: Charlotte Andriessen Department of Nutrition and Movement Sciences Maastricht University
WeightControl.com: What is the background for this study? What are the main findings?
Response: In our modern 24h society, most people spread their food intake over at least 14 hours per day. As such, they lack a pronounced fasting state during the night and energy stores are hardly being depleted. Here, we wanted to re-store this pronounced overnight fast in people with type 2 diabetes, by limiting their habitual food intake to a 10-hour daily time window (time restricted eating, TRE) for a period of 3 weeks.
We hypothesized that the utilization of energy stores during the night would increase the need to re-fuel these stores with the first meal of the day, and would therefore result in a better energy uptake via the hormone insulin; i.e. would result in better insulin sensitivity. Although we did not find insulin sensitivity to be increased with TRE, we did find that fasting- and 24h glucose levels were decreased as compared to our control condition, in which participants spread their habitual food intake over at least 14 hours per day. Moreover, our volunteers spent more time in the normal glucose range, whereas the time restricted eating regime did not increase the time spent in hypoglyceamia.
The main messages are that the liver can directly control the most complex part of the brain.
WeightControl.com Interview with: Tamas L. Horvath, DVM, PhD Jean and David W. Wallace Professor of Comparative Medicine Chair, Department of Comparative Medicine Founding Director, Yale Program in Integrative Cell Signaling & Neurobiology of Metabolism Professor of Neuroscience and Ob/Gyn & Reproductive Sciences Yale University School of Medicine
WeightControl.comWhat is the background for this study? What are the main findings?
Response: We knew from earlier work that this very specific lipid species we studied (lysophospholipids) have an impact on how the most complex part of our brain, the cerebral cortex, functions. What is knew here is that we show that the level of these lipids fluctuate in association with the level of hunger of animals and that this fluctuation of these liver-derived lipid molecules are governed by neurons that control hunger and are in an ancient part of the brain (hypothalamus).