Weight Control at WeightControl.com

Cleveland Clinic Study Identifies Factors Associated with Weight Loss Success on Semaglutide or Liraglutide

Researchers found that four in 10 patients (40.7%) were persistent with their medication one year after their initial prescription’s fill. The proportion of patients who were persistent with semaglutide was 45.8% versus 35.6% in patients receiving liraglutide.

WeightControl.com Interview with:
Hamlet Gasoyan, Ph.D.
Lead author of the study and Researcher
Center for Value-Based Care Research
Cleveland Clinic

WeightControl.com: What is the background for this study?

Response: Recently, injectable forms of GLP-1 RA medications such as semaglutide have been more commonly prescribed, in part related to their ability to demonstrate clinically significant weight reduction. However, outside of randomized trial settings, data on weight loss with semaglutide or liraglutide for obesity is generally limited to 6 months of follow-up, based on brand names approved by the FDA for type 2 diabetes only, or cohorts that exclude patients who did not persist with the medication.

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Increased BMI in Teens Whose Parents were Obese in Adolescence

Knowing that offsprings of parents with obesity are at a greater risk than other children for being overweight at adolescence, the question remains what are the epigenetic factors that affect obesity.

WeightControl.com Interview with:
Gilad Twig, MD, MPH, PhD
Head of the Population Health Research Center
Sheba Medical Center, Ramat Gan, Israel.
Associate Professor, Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medicine
Tel-Aviv University, Tel-Aviv, Israel

WeightControl.com: What is the background for this study?

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Response: Heritability of obesity has been widely investigated, but when parental and children’s body weights are compared it is difficult to distinguish between genetic relationship and shared lifestyle. In this study we compared parents and their children’s body weights all measured at age 17.

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Even Small Reductions in Weight Can Reduce Obesity-Related Chronic Diseases

Given the health benefits of clinically meaningful weight reduction at any level of excess weight, 5% or greater weight loss can be a reasonable target for obesity management efforts.

WeightControl.com Interview with:

Dr. Lyudmyla Kompaniyets, PhD
Division of Nutrition, Physical Activity and Obesity
National Center for Chronic Disease Prevention and Health Promotion
Centers for Disease Control and Prevention, Atlanta, Georgia

WeightControl.com: What is the background for this study?

Response: Overweight and obesity affect more than 70% of US adults and are risk factors for other chronic diseases, including type 2 diabetes, cardiovascular disease, and many cancers. This is one of the only papers to assess the probability of a 5% weight loss or reducing BMI to healthy weight among US adults with overweight and obesity.

This study focused on the probability of weight loss in a healthcare seeking population with overweight or obesity regardless of any individual’s intention to lose weight.

Small Weight Loss in Older Men Might Signify Increased Risk of Mortality

Older individuals with a weight loss of 5-10% had a higher risk of all-cause mortality: 33% for men and 26% for women.

WeightControl.com Interview with:
Dr Monira Hussain MBBS, MPH, PhD
Senior Research Fellow &
ECF Clinical Research Australian Fellow
Public Health and Preventive Medicine
Monash University
Melbourne Australia

Dr Monira Hussain MBBS, MPH, PhD
Senior Research Fellow &
ECF Clinical Research Australian Fellow
Public Health and Preventive Medicine
Monash University
Melbourne Australia

WeightControl.com: What is the background for this study?

Response: The impact of weight changes on healthy older adults is not fully understood, and the association between weight loss and cause-specific mortality needs to be explored using more reliable methods.

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