Yale Scientists Find Liver and Brain Work Together to Control Eating

The main messages are that the liver can directly control the most complex part of the brain.

WeightControl.com What should readers take away from your report?

Response: The main messages are that the liver can directly control the most complex part of the brain, and that the ancient part of the brain communicates with the most sophisticated brain region via a peripheral organ.

WeightControl.com What recommendations do you have for future research as a result of this work?

Response: One recommendation is that if one wants to understand how higher brain regions of the brain function and dysfunction (for example eating disorders or  schizophrenia), the rest of the body, such as the liver, need to be considered as well.  Contemporary neuroscience does not pay sufficient attention to these critical issues.     

Disclosures: : I have no interest in any for profit entity associated with the work.


Heiko Endle, Guilherme Horta, Bernardo Stutz, Muthuraman Muthuraman, Irmgard Tegeder, Yannick Schreiber, Isabel Faria Snodgrass, Robert Gurke, Zhong-Wu Liu, Matija Sestan-Pesa, Konstantin Radyushkin, Nora Streu, Wei Fan, Jan Baumgart, Yan Li, Florian Kloss, Sergiu Groppa, Nils Opel, Udo Dannlowski, Hans J. Grabe, Frauke Zipp, Bence Rácz, Tamas L. Horvath, Robert Nitsch, Johannes Vogt. AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids. Nature Metabolism, 2022; 4 (6): 683 DOI: 10.1038/s42255-022-00589-7

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Last Updated on June 30, 2022 by weightcontrol