Weight Control at WeightControl.com

ECO24: Ideal Weight For Patients with Diabetes May Vary with Age

For older individuals who are moderately overweight , maintaining rather than reducing weight may be a more practical goal.

WeightControl.com Interview with:
Dr Shaoyong Xu
Xiangyang Central Hospital
Affiliated Hospital of Hubei University of Arts and Science
Xiangyang, China

WeightControl.com: What is the background for this study?

Response: In previous studies, the obesity paradox has been observed, where overweight and obese individuals with cardiovascular disease have better outcomes compared to their slim counterparts with the same disease. The global prevalence of diabetes is steadily increasing year by year.

In this era of population growth and aging, the question arises as to whether obesity or overweight can be beneficial in improving survival rates for older individuals with diabetes. This topic holds significant relevance due to the potential implications it has on weight management strategies for older adults. If overweight does not pose an increased risk of cardiovascular mortality, it may suggest that older individuals are not necessarily required to strive for weight loss in order to achieve so-called normal values. Moreover, inappropriate weight loss and being underweight could potentially elevate the risk of cardiovascular events, myocardial infarction, cerebral infarction, and all-cause mortality.

Pages: 12

More than Just for Diabetes: SGLT2 Inhibitors Benefit Patients with Heart Failure

SGLT2 inhibitors, from being merely an antidiabetic drug, are contributing a lot to the global fight against cardiovascular and renal diseases.

WeightControl.com Interview with:
Bernardo Cortese, MD FESC FSCAI
Interventional Cardiologist
President, Scientific Committee Fondazione Ricerca e Innovazione Cardiovascolare,
CEO, DCB Academy
www.fondazioneric.org
www.bernardocortese.com

WeightControl.com: What is the background for this study? What are the main findings?

Response: Our report seeks to elucidate the current role of SGLT2 inhibitors in the management of cardiovascular disease and the comprehensive spectrum of heart failure, namely when the heart start deteriorating in its functions.

We start focusing on the pharmacological properties of this class of drugs, thereafter we go through a synthesis and analysis of data derived from the main clinical trials which have involved this class when applied to the cardiovascular patient. Specifically, we aim to consolidate findings that substantiate the safety profile of SGLT2 inhibitors concerning cardiac, renal, and metabolic parameters. Furthermore, our study explores the therapeutic impact of these agents in the context of managing and treating type 2 diabetes.

These “glucoscape maestros”, initially prescribed to diabetic patients, showed a great safety and benefit profile in patients with renal impairment and, most importantly, with a failing heart.

Pages: 12

Lean Individuals Who Intentionally Lose Weight May Risk Diabetes and Inceased Weight Gain

Exercise is optimal for long-term weight control and prevention of type 2 diabetes when compared with low-calorie diet, low-calorie diet & exercise, fasting, commercial weight loss program, and diet pills.

WeightControl.com Interview with:
Dr. Keyi Si, PhD
Department of Nutrition
Harvard T.H. Chan School of Public Health

WeightControl.com: What is the background for this study?

Response: Weight control is one of the primary and effective strategies for the prevention and management of obesity and related chronic diseases. However, long-term weight change and risks of developing type 2 diabetes following various weight loss strategies are understudied, especially among originally lean individuals.

Pages: 12

Time Restricted Eating Reduced Glucose Levels Study of Type 2 Diabetes

For our study, the time window in which participants were allowed to eat was delibarately set to daytime, with the last meal being ingested at 6 PM the latest. We did this so that the time-window fits in the natural, internal day-night rhythm of humans.

WeightControl.com Interview with:
Charlotte Andriessen
Department of Nutrition and Movement Sciences
Maastricht University

WeightControl.com: What is the background for this study? What are the main findings?

Response: In our modern 24h society, most people spread their food intake over at least 14 hours per day. As such, they lack a pronounced fasting state during the night and energy stores are hardly being depleted. Here, we wanted to re-store this pronounced overnight fast in people with type 2 diabetes, by limiting their habitual food intake to a 10-hour daily time window (time restricted eating, TRE) for a period of 3 weeks.

We hypothesized that the utilization of energy stores during the night would increase the need to re-fuel these stores with the first meal of the day, and would therefore result in a better energy uptake via the hormone insulin; i.e. would result in better insulin sensitivity. Although we did not find insulin sensitivity to be increased with TRE, we did find that fasting- and 24h glucose levels were decreased as compared to our control condition, in which participants spread their habitual food intake over at least 14 hours per day. Moreover, our volunteers spent more time in the normal glucose range, whereas the time restricted eating regime did not increase the time spent in hypoglyceamia.