Hopkins Study finds Weight Loss by Bariatric Embolization Principally from Fatty Tissues

The data from this preliminary study represents a healthy pattern of weight loss in support of bariatric embolization as a valid therapeutic for obesity.

WeightControl.com Interview with:

Daniel Giraldo-Herrera, MD,
Postdoctoral research fellow
Johns Hopkins University School of Medicine and
Clifford R. Weiss, MD, PI of the study
Professor of Radiology and Biomedical Engineering
Johns Hopkins University School of Medicine, and
Whiting School of Engineering.

WeightControl.com:  What is the background for this study? Would you describe the procedure and how it works to reduce obesity?

Response: Bariatric Embolization is a minimally invasive image-guided medical procedure for patients with morbid obesity who seek weight loss. The procedure is performed with tiny catheters through small nicks in the skin, deploying precisely engineered microscopic beads. These are deposited to block blood flow in the upper part of the stomach to reduce appetite by suppressing the release of the hunger-stimulating hormone ghrelin. With less hunger, patients can then more easily restrict excess calories from food intake. Weight loss results as they tap their own caloric energy reserves, ideally from subcutaneous fat (the deposits between the skin and deep muscle tissues) and visceral fat (the deposits surrounding abdominal organs). Protein stored in muscle can also be turned to calories for energy.

The purpose of this study was to understand if weight loss resulting from Bariatric Embolization comes from fat, muscle, or a mix of both. In a pilot trial, we used AMRA Medical’s advanced body composition measurement techniques with magnetic resonance imaging (MRI) to determine body composition changes in the abdomen and thighs, where the most significant fat deposits and muscle groups are located. MRI is the reference standard for body composition measurement since it allows for rapid, detailed analysis of anatomic distributions and accurate measurement of fat and muscle tissue volumes.

Intermittent Fasting Plus Exercise Can Reduce Help Decrease Liver Fat

Fatty liver disease puts people at high risk of developing type 2 diabetes.

WeightControl.com Interview with:
Krista Varady, PhD
Professor of Nutrition
Dept Kinesiology and Nutrition
University of Illinois Chicago
Chicago, Illinois, 60612
Instagram: @DrKristaVarady

WeightControl.com:  What is the background for this study? 

Response: We noticed that the main lifestyle therapy for non-alcoholic fatty liver disease (NAFLD) was combining daily calorie restriction with aerobic exercise. We were curious if intermittent fasting combined with aerobic exercise would produce the same reductions in liver fat.

So we designed a randomized controlled trial in 80 adults with obesity and NAFLD, with four intervention groups:

1) An alternate day fasting group that consumed 500 calories on the “fast day”, alternated with a free eating “feast day”;

2) Exercise group that participated in five supervised 60 min sessions per week, using elliptical machines and treadmills;

3) Combination of the fasting and exercise interventions;

4) No intervention control group. We measured liver fat using MRI before and after the 3-month intervention.

NEJM: Semaglutide Evaluated for Pediatric Obesity

WeightControl.com Interview with:
Prof. Dr. Daniel Weghuber
Head of Department
Department of Pediatrics
Paracelsus Medical University
President of the European Childhood Obesity Group

Prof. Dr. Weghuber

WeightControl.com:  What is the background for this study? 

Response: In this study, researchers looked at the effect of semaglutide on body mass index (BMI) and weight loss compared to a dummy medicine (placebo).

ObesityWeek: Setmelanotide (IMCIVREE™) Successfully Induced Weight Loss in Patients With Hypothalamic Obesity

Patients were able to stay away from food for a longer time. For some of the patients that was really changing their lives. They are back to normal and not obsessed with food all the time.

WeightControl.com Interview with:
Dr. Christian Roth, MD
Seattle Children’s Research Institute and Division of Endocrinology
Department of Pediatrics
University of Washington

Dr. Christian Roth, MD
Seattle Children’s Research Institute and Division of Endocrinology
Department of Pediatrics
University of Washington
Dr. Roth

WeightControl.com:  What is the background for this study? Would you briefly explain what is meant by Hypothalamic Obesity?

Response: Hypothalamic obesity is a different entity of obesity that is rare and very difficult to treat. It is an acquired form of obesity due to injury to the hypothalamus because of a brain tumor and/or its treatment. This causes an abrupt change in body weight regulation because tissues that are important for energy homeostasis are partially or completely removed.

Typically, these patients can’t control their appetite and within a very short time after surgery they gain weight quickly. Their energy expenditure is also very low. So even if they cut down on calorie intake, they are typically not able to lose weight.

Gender Differences in Weight Loss with Medical Treatments

females lost more weight than males with similar exposures to liraglutide, suggesting that body size may not be the only factor.

WeightControl.com Interview with:
A/Prof Samantha L Hocking | Associate Professor Diabetes NSW & ACT
Sydney School of Medicine (Central Clinical School)
Charles Perkins Centre
Faculty of Medicine and Health
President National Association of Clinical Obesity Services

WeightControl.com:  What is the background for this study? 

Response: Numerous studies have shown that the mean response to a weight loss intervention hides significant individual variation. There are biological and physiological differences between males and females so gender is a potential predictor of weight loss outcomes. 

Genetic Platform Can Allow Some Meds to Be Repurposed for Obesity and Type 2 Diabetes

In the current project we developed genetically informed repurposed medications to tackle obesity and type 2 diabetes (T2D)

WeightControl.com Interview with:
Professor Murray Cairns. 
Sahar El Shair, PhD student
University of Newcastle, NSW, Australia

WeightControl.com:  What is the background for this study? 

Response: The background is that we want to improve global health by making a significant impact on chronic disease. Many of these complex disorders have a substantial genetic risk but this risk involves hundreds of genes (unlike the simple genetic disorders that people are more familiar with caused by a single gene) and manifests differently in different people.

To break through this problem we developed a platform for aggregating and scoring an individual’s risk for complex disorders in gene networks that can be modulated by drugs. This includes new drugs, existing drugs and those that are currently used for other conditions.  

PostPartum Instagram Pics Most Often Idealized Athletic Images

Women with lower body fat, and in fitness attire, are more likely to post images of themselves on Instagram than women of higher adiposity.

WeightControl.com Interview with:
Dr Megan Gow 
NHMRC Early Career Fellow
Research Dietitian and Senior Lecturer
The University of Sydney Children’s Hospital Westmead Clinical School
Adjunct Senior Lecturer, Women’s and Children’s Health, UNSW
Honorary Research Associate, Women’s and Children’s Health,
St George Hospital

WeightControl.com:  What is the background for this study? 

Response: Research has already established that Instagram use is associated with negative impacts on mood and body satisfaction in young women. However, Instagram is highly accessed by women of reproductive age. We assessed 600 images tagged with #postpartumbody systematically captured from Instagram and coded them using a predefined framework.

Lean Individuals Who Intentionally Lose Weight May Risk Diabetes and Inceased Weight Gain

Exercise is optimal for long-term weight control and prevention of type 2 diabetes when compared with low-calorie diet, low-calorie diet & exercise, fasting, commercial weight loss program, and diet pills.

WeightControl.com Interview with:
Dr. Keyi Si, PhD
Department of Nutrition
Harvard T.H. Chan School of Public Health

Dr. Keyi Si

WeightControl.com:  What is the background for this study? 

Response: Weight control is one of the primary and effective strategies for the prevention and management of obesity and related chronic diseases. However, long-term weight change and risks of developing type 2 diabetes following various weight loss strategies are understudied, especially among originally lean individuals.

Study Finds Morning or Evening Calories Equally Affect Weight Loss

However, people who ate their largest meal in the morning did report feeling less hungry later in the day, which could foster easier weight loss in the real world.

WeightControl.com Interview with:
Prof Alexandra Johnstone
Rowett Institute
University of Aberdeen

WeightControl.com:  What is the background for this study? 

Response: There are a lot of myths surrounding the timing of eating and how it might influence either body weight or health. When dieting, many people follow the old saying “breakfast like a king, lunch like a prince, and dine like a pauper,” based on the belief that consuming the bulk of daily calories in the morning optimizes weight loss by burning calories more efficiently.

Model Predicts Success of Weight Control Programs

We know that many people living with obesity do not want to attend health care appointments after a perceived “failure” of a weight loss intervention

WeightControl.com Interview with:
Prof Jennifer Logue 
Associate Dean (Research) Faculty of Health and Medicine
Lancaster University
Deputy Clinical Director | NIHR CRN North West Coast
Professor of Metabolic Medicine | Lancaster University
Hon Consultant in Metabolic Medicine
Blackpool Victoria Hospital

WeightControl.com:  What is the background for this study? 

Response: Currently, many providers may offer more intensive therapies to every patient as they don’t believe behavioural programmes are effective, when they are for many people. Other providers leave patients struggling in a behavioural programme and they will disengage, reinforcing self-stigma.