ObesityWeek: Setmelanotide (IMCIVREE™) Successfully Induced Weight Loss in Patients With Hypothalamic Obesity

Patients were able to stay away from food for a longer time. For some of the patients that was really changing their lives. They are back to normal and not obsessed with food all the time.

WeightControl.com Interview with:
Dr. Christian Roth, MD
Seattle Children’s Research Institute and Division of Endocrinology
Department of Pediatrics
University of Washington

Dr. Christian Roth, MD
Seattle Children’s Research Institute and Division of Endocrinology
Department of Pediatrics
University of Washington
Dr. Roth

WeightControl.com:  What is the background for this study? Would you briefly explain what is meant by Hypothalamic Obesity?

Response: Hypothalamic obesity is a different entity of obesity that is rare and very difficult to treat. It is an acquired form of obesity due to injury to the hypothalamus because of a brain tumor and/or its treatment. This causes an abrupt change in body weight regulation because tissues that are important for energy homeostasis are partially or completely removed.

Typically, these patients can’t control their appetite and within a very short time after surgery they gain weight quickly. Their energy expenditure is also very low. So even if they cut down on calorie intake, they are typically not able to lose weight.

Gender Differences in Weight Loss with Medical Treatments

females lost more weight than males with similar exposures to liraglutide, suggesting that body size may not be the only factor.

WeightControl.com Interview with:
A/Prof Samantha L Hocking | Associate Professor Diabetes NSW & ACT
Sydney School of Medicine (Central Clinical School)
Charles Perkins Centre
Faculty of Medicine and Health
President National Association of Clinical Obesity Services

WeightControl.com:  What is the background for this study? 

Response: Numerous studies have shown that the mean response to a weight loss intervention hides significant individual variation. There are biological and physiological differences between males and females so gender is a potential predictor of weight loss outcomes. 

Genetic Platform Can Allow Some Meds to Be Repurposed for Obesity and Type 2 Diabetes

In the current project we developed genetically informed repurposed medications to tackle obesity and type 2 diabetes (T2D)

WeightControl.com Interview with:
Professor Murray Cairns. 
Sahar El Shair, PhD student
University of Newcastle, NSW, Australia

WeightControl.com:  What is the background for this study? 

Response: The background is that we want to improve global health by making a significant impact on chronic disease. Many of these complex disorders have a substantial genetic risk but this risk involves hundreds of genes (unlike the simple genetic disorders that people are more familiar with caused by a single gene) and manifests differently in different people.

To break through this problem we developed a platform for aggregating and scoring an individual’s risk for complex disorders in gene networks that can be modulated by drugs. This includes new drugs, existing drugs and those that are currently used for other conditions.  

PostPartum Instagram Pics Most Often Idealized Athletic Images

Women with lower body fat, and in fitness attire, are more likely to post images of themselves on Instagram than women of higher adiposity.

WeightControl.com Interview with:
Dr Megan Gow 
NHMRC Early Career Fellow
Research Dietitian and Senior Lecturer
The University of Sydney Children’s Hospital Westmead Clinical School
Adjunct Senior Lecturer, Women’s and Children’s Health, UNSW
Honorary Research Associate, Women’s and Children’s Health,
St George Hospital

WeightControl.com:  What is the background for this study? 

Response: Research has already established that Instagram use is associated with negative impacts on mood and body satisfaction in young women. However, Instagram is highly accessed by women of reproductive age. We assessed 600 images tagged with #postpartumbody systematically captured from Instagram and coded them using a predefined framework.

Lean Individuals Who Intentionally Lose Weight May Risk Diabetes and Inceased Weight Gain

Exercise is optimal for long-term weight control and prevention of type 2 diabetes when compared with low-calorie diet, low-calorie diet & exercise, fasting, commercial weight loss program, and diet pills.

WeightControl.com Interview with:
Dr. Keyi Si, PhD
Department of Nutrition
Harvard T.H. Chan School of Public Health

Dr. Keyi Si

WeightControl.com:  What is the background for this study? 

Response: Weight control is one of the primary and effective strategies for the prevention and management of obesity and related chronic diseases. However, long-term weight change and risks of developing type 2 diabetes following various weight loss strategies are understudied, especially among originally lean individuals.

Study Finds Morning or Evening Calories Equally Affect Weight Loss

However, people who ate their largest meal in the morning did report feeling less hungry later in the day, which could foster easier weight loss in the real world.

WeightControl.com Interview with:
Prof Alexandra Johnstone
Rowett Institute
University of Aberdeen

WeightControl.com:  What is the background for this study? 

Response: There are a lot of myths surrounding the timing of eating and how it might influence either body weight or health. When dieting, many people follow the old saying “breakfast like a king, lunch like a prince, and dine like a pauper,” based on the belief that consuming the bulk of daily calories in the morning optimizes weight loss by burning calories more efficiently.

Model Predicts Success of Weight Control Programs

We know that many people living with obesity do not want to attend health care appointments after a perceived “failure” of a weight loss intervention

WeightControl.com Interview with:
Prof Jennifer Logue 
Associate Dean (Research) Faculty of Health and Medicine
Lancaster University
Deputy Clinical Director | NIHR CRN North West Coast
Professor of Metabolic Medicine | Lancaster University
Hon Consultant in Metabolic Medicine
Blackpool Victoria Hospital

WeightControl.com:  What is the background for this study? 

Response: Currently, many providers may offer more intensive therapies to every patient as they don’t believe behavioural programmes are effective, when they are for many people. Other providers leave patients struggling in a behavioural programme and they will disengage, reinforcing self-stigma.

Time Restricted Eating Reduced Glucose Levels Study of Type 2 Diabetes

​For our study, the time window in which participants were allowed to eat was delibarately set to daytime, with the last meal being ingested at 6 PM the latest. We did this so that the time-window fits in the natural, internal day-night rhythm of humans.

WeightControl.com Interview with:
Charlotte Andriessen
Department of Nutrition and Movement Sciences
Maastricht University

WeightControl.com:  What is the background for this study?  What are the main findings?

Response: In our modern 24h society, most people spread their food intake over at least 14 hours per day. As such, they lack a pronounced fasting state during the night and energy stores are hardly being depleted. Here, we wanted to re-store this pronounced overnight fast in people with type 2 diabetes, by limiting their habitual food intake to a 10-hour daily time window (time restricted eating, TRE) for a period of 3 weeks.

We hypothesized that the utilization of energy stores during the night would increase the need to re-fuel these stores with the first meal of the day, and would therefore result in a better energy uptake via the hormone insulin; i.e. would result in better insulin sensitivity. Although we did not find insulin sensitivity to be increased with TRE, we did find that fasting- and 24h glucose levels were decreased as compared to our control condition, in which participants spread their habitual food intake over at least 14 hours per day. Moreover, our volunteers spent more time in the normal glucose range, whereas the time restricted eating regime did not increase the time spent in hypoglyceamia. 

Continue reading “Time Restricted Eating Reduced Glucose Levels Study of Type 2 Diabetes”

Yale Scientists Find Liver and Brain Work Together to Control Eating

The main messages are that the liver can directly control the most complex part of the brain.

WeightControl.com Interview with:
Tamas L. Horvath, DVM, PhD
Jean and David W. Wallace Professor of Comparative Medicine
Chair, Department of Comparative Medicine
Founding Director, Yale Program in Integrative Cell Signaling
& Neurobiology of Metabolism
Professor of Neuroscience and Ob/Gyn & Reproductive Sciences
Yale University School of Medicine

WeightControl.com What is the background for this study?  What are the main findings?

Response: We knew from earlier work that this very specific lipid species we studied (lysophospholipids) have an impact on how the most complex part of our brain, the cerebral cortex, functions.  What is knew here is that we show that the level of these lipids fluctuate in association with the level of hunger of animals and that this fluctuation of these liver-derived lipid molecules are governed by neurons that control hunger and are in an ancient part of the brain (hypothalamus).   

New Weight Loss Model Targets Individual Response to Food Cues

Individuals who are high on food cue responsiveness typically have uncontrolled eating and ruminate (think) about food a lot of the time

WeightControl.com Interview with:

Dr. Kerri N. Boutelle, Ph.D
Department of Pediatrics
Herbert Wertheim School of Public Health and Human Longevity Science,
Department of Psychiatry
University of California, San Diego, La Jolla, California

WeightControl.com:  What is the background for this study?  What are the main findings?

Response: Behavioral weight loss, which includes nutrition and physical activity education and behavior therapy techniques (also called a lifestyle intervention), is not effective for all adults with overweight and obesity and of those who lose weight, the majority regain the weight back.  This suggests that there are unaddressed underlying mechanisms that impact the effectiveness of these interventions. 

We developed a novel weight loss model based on appetitive traits, called regulation of cues (roc), that targets improving responsiveness to hunger and satiety cues and decreasing responsiveness to food cues.  This is different than behavioral weight loss as it targets these internal control mechanisms while behavioral weight loss targets external control mechanisms.