Gender Differences in Core Body Temperature

WeightControl.com Interview with:
Reed Thomas BS and
Dr. Kong Y. Chen PhD
Director, Human Energy & Body Weight Regulation Core
NIH

WeightControl.com:  What is the background for this study? 

Response: Over the last century, many studies have looked at the thermoregulation of both arctic and tropical animals; however, far fewer have rigorously measured variations in human thermal physiology, and even less have compared women and men. This study is a part of our ongoing efforts to fill that gap.

Variety of Healthy Dietary Patterns can be Recommended to Reduce Risk of Chronic Diseases and Premature Death

These patterns such as the Mediterranean diet, DASH diet, vegetarian diet, or other versions of healthy diets can be adapted to meet individual health needs, food preferences, and cultural traditions.

WeightControl.com Interview with:
Frank B. Hu, MD, PhD
Professor and Chair
Department of Nutrition
Harvard T.H. Chan School of Public Health

Dr. Frank Hu

WeightControl.com:  What is the background for this study? What are the main findings?

Response: The current Dietary Guidelines for Americans (DGAs) recommend multiple healthy eating patterns. However, few studies have evaluated whether greater adherence to the DGAs-recommended dietary patterns is associated with long-term risk of total and cause-specific mortality. The researchers used health data collected over 36 years from 75,230 women participating in the Nurses’ Health Study and 44,085 men in the Health Professionals Follow-up Study. All participants were free of cardiovascular disease or cancer at the beginning of the study and completed dietary questionnaires every four years.

Their information was scored based on each of the four dietary pattern indexes (Healthy Eating Index 2015, Alternate Mediterranean Diet, Healthful Plant-based Diet Index, and Alternate Healthy Eating Index). All share key components including whole grains, fruits, vegetables, nuts, and legumes, although other components differ across different eating patterns. 

Small Weight Loss in Older Men Might Signify Increased Risk of Mortality

Older individuals with a weight loss of 5-10% had a higher risk of all-cause mortality: 33% for men and 26% for women.

WeightControl.com Interview with:
Dr Monira Hussain MBBS, MPH, PhD
Senior Research Fellow & 
ECF Clinical Research Australian Fellow 
Public Health and Preventive Medicine
Monash University
Melbourne Australia

Dr Monira Hussain MBBS, MPH, PhD
Senior Research Fellow & 
ECF Clinical Research Australian Fellow 
Public Health and Preventive Medicine
Monash University
Melbourne Australia

WeightControl.com:  What is the background for this study? 

Response: The impact of weight changes on healthy older adults is not fully understood, and the association between weight loss and cause-specific mortality needs to be explored using more reliable methods.

ObesityWeek: Setmelanotide (IMCIVREE™) Successfully Induced Weight Loss in Patients With Hypothalamic Obesity

Patients were able to stay away from food for a longer time. For some of the patients that was really changing their lives. They are back to normal and not obsessed with food all the time.

WeightControl.com Interview with:
Dr. Christian Roth, MD
Seattle Children’s Research Institute and Division of Endocrinology
Department of Pediatrics
University of Washington

Dr. Christian Roth, MD
Seattle Children’s Research Institute and Division of Endocrinology
Department of Pediatrics
University of Washington
Dr. Roth

WeightControl.com:  What is the background for this study? Would you briefly explain what is meant by Hypothalamic Obesity?

Response: Hypothalamic obesity is a different entity of obesity that is rare and very difficult to treat. It is an acquired form of obesity due to injury to the hypothalamus because of a brain tumor and/or its treatment. This causes an abrupt change in body weight regulation because tissues that are important for energy homeostasis are partially or completely removed.

Typically, these patients can’t control their appetite and within a very short time after surgery they gain weight quickly. Their energy expenditure is also very low. So even if they cut down on calorie intake, they are typically not able to lose weight.

Gender Differences in Weight Loss with Medical Treatments

females lost more weight than males with similar exposures to liraglutide, suggesting that body size may not be the only factor.

WeightControl.com Interview with:
A/Prof Samantha L Hocking | Associate Professor Diabetes NSW & ACT
Sydney School of Medicine (Central Clinical School)
Charles Perkins Centre
Faculty of Medicine and Health
President National Association of Clinical Obesity Services

WeightControl.com:  What is the background for this study? 

Response: Numerous studies have shown that the mean response to a weight loss intervention hides significant individual variation. There are biological and physiological differences between males and females so gender is a potential predictor of weight loss outcomes. 

Lean Individuals Who Intentionally Lose Weight May Risk Diabetes and Inceased Weight Gain

Exercise is optimal for long-term weight control and prevention of type 2 diabetes when compared with low-calorie diet, low-calorie diet & exercise, fasting, commercial weight loss program, and diet pills.

WeightControl.com Interview with:
Dr. Keyi Si, PhD
Department of Nutrition
Harvard T.H. Chan School of Public Health

Dr. Keyi Si

WeightControl.com:  What is the background for this study? 

Response: Weight control is one of the primary and effective strategies for the prevention and management of obesity and related chronic diseases. However, long-term weight change and risks of developing type 2 diabetes following various weight loss strategies are understudied, especially among originally lean individuals.

Model Predicts Success of Weight Control Programs

We know that many people living with obesity do not want to attend health care appointments after a perceived “failure” of a weight loss intervention

WeightControl.com Interview with:
Prof Jennifer Logue 
Associate Dean (Research) Faculty of Health and Medicine
Lancaster University
Deputy Clinical Director | NIHR CRN North West Coast
Professor of Metabolic Medicine | Lancaster University
Hon Consultant in Metabolic Medicine
Blackpool Victoria Hospital

WeightControl.com:  What is the background for this study? 

Response: Currently, many providers may offer more intensive therapies to every patient as they don’t believe behavioural programmes are effective, when they are for many people. Other providers leave patients struggling in a behavioural programme and they will disengage, reinforcing self-stigma.

Yale Scientists Find Liver and Brain Work Together to Control Eating

The main messages are that the liver can directly control the most complex part of the brain.

WeightControl.com Interview with:
Tamas L. Horvath, DVM, PhD
Jean and David W. Wallace Professor of Comparative Medicine
Chair, Department of Comparative Medicine
Founding Director, Yale Program in Integrative Cell Signaling
& Neurobiology of Metabolism
Professor of Neuroscience and Ob/Gyn & Reproductive Sciences
Yale University School of Medicine

WeightControl.com What is the background for this study?  What are the main findings?

Response: We knew from earlier work that this very specific lipid species we studied (lysophospholipids) have an impact on how the most complex part of our brain, the cerebral cortex, functions.  What is knew here is that we show that the level of these lipids fluctuate in association with the level of hunger of animals and that this fluctuation of these liver-derived lipid molecules are governed by neurons that control hunger and are in an ancient part of the brain (hypothalamus).   

New Weight Loss Model Targets Individual Response to Food Cues

Individuals who are high on food cue responsiveness typically have uncontrolled eating and ruminate (think) about food a lot of the time

WeightControl.com Interview with:

Dr. Kerri N. Boutelle, Ph.D
Department of Pediatrics
Herbert Wertheim School of Public Health and Human Longevity Science,
Department of Psychiatry
University of California, San Diego, La Jolla, California

WeightControl.com:  What is the background for this study?  What are the main findings?

Response: Behavioral weight loss, which includes nutrition and physical activity education and behavior therapy techniques (also called a lifestyle intervention), is not effective for all adults with overweight and obesity and of those who lose weight, the majority regain the weight back.  This suggests that there are unaddressed underlying mechanisms that impact the effectiveness of these interventions. 

We developed a novel weight loss model based on appetitive traits, called regulation of cues (roc), that targets improving responsiveness to hunger and satiety cues and decreasing responsiveness to food cues.  This is different than behavioral weight loss as it targets these internal control mechanisms while behavioral weight loss targets external control mechanisms.

After Bariatric Surgery, Women Advised to Wait At Least Two Years to Conceive

After bariatric surgery there is a rapid weight loss that may impair an adequate weight gain during pregnancy and may also be associated with nutritional deficiencies

WeightControl.com Interview with:
Dr Ana Carreira and Dr Bárbara Araújo
Department of Endocrinology and Metabolism
Centro Hospitalar e Universitário de Coimbra
Coimbra, Portuga

WeightControl.com:  What is the background for this study? 

Response: Bariatric surgery is increasingly common in women of reproductive age and reduces the risk of obesity-related comorbidities in pregnancy. However, women after bariatric surgery have an increased risk of having a baby who is underweight (small for gestational age, SGA). A shorter bariatric surgery-to-conception interval (BSCI) has been one of the factors associated with a higher risk of SGA neonates, and, as a result, women are generally advised to wait at least 12 months after bariatric surgery before trying to conceive. However, the optimal bariatric surgery-to-conception interval is yet to be determined, and current recommendation differ among scientific societies, with some advocating a minimum of 12months and others 18 or 24 months.