WeightControl.com Interview with: Reed Thomas BS and Dr. Kong Y. Chen PhD Director, Human Energy & Body Weight Regulation Core NIH
WeightControl.com: What is the background for this study?
Response: Over the last century, many studies have looked at the thermoregulation of both arctic and tropical animals; however, far fewer have rigorously measured variations in human thermal physiology, and even less have compared women and men. This study is a part of our ongoing efforts to fill that gap.
These patterns such as the Mediterranean diet, DASH diet, vegetarian diet, or other versions of healthy diets can be adapted to meet individual health needs, food preferences, and cultural traditions.
WeightControl.com Interview with: Frank B. Hu, MD, PhD Professor and Chair Department of Nutrition Harvard T.H. Chan School of Public Health
WeightControl.com: What is the background for this study? What are the main findings?
Response: The current Dietary Guidelines for Americans (DGAs) recommend multiple healthy eating patterns. However, few studies have evaluated whether greater adherence to the DGAs-recommended dietary patterns is associated with long-term risk of total and cause-specific mortality. The researchers used health data collected over 36 years from 75,230 women participating in the Nurses’ Health Study and 44,085 men in the Health Professionals Follow-up Study. All participants were free of cardiovascular disease or cancer at the beginning of the study and completed dietary questionnaires every four years.
Their information was scored based on each of the four dietary pattern indexes (Healthy Eating Index 2015, Alternate Mediterranean Diet, Healthful Plant-based Diet Index, and Alternate Healthy Eating Index). All share key components including whole grains, fruits, vegetables, nuts, and legumes, although other components differ across different eating patterns.
Older individuals with a weight loss of 5-10% had a higher risk of all-cause mortality: 33% for men and 26% for women.
WeightControl.com Interview with: Dr Monira Hussain MBBS, MPH, PhD Senior Research Fellow & ECF Clinical Research Australian Fellow Public Health and Preventive Medicine Monash University Melbourne Australia
WeightControl.com: What is the background for this study?
Response: The impact of weight changes on healthy older adults is not fully understood, and the association between weight loss and cause-specific mortality needs to be explored using more reliable methods.
Patients were able to stay away from food for a longer time. For some of the patients that was really changing their lives. They are back to normal and not obsessed with food all the time.
WeightControl.com Interview with: Dr. Christian Roth, MD Seattle Children’s Research Institute and Division of Endocrinology Department of Pediatrics University of Washington
WeightControl.com: What is the background for this study? Would you briefly explain what is meant by Hypothalamic Obesity?
Response: Hypothalamic obesity is a different entity of obesity that is rare and very difficult to treat. It is an acquired form of obesity due to injury to the hypothalamus because of a brain tumor and/or its treatment. This causes an abrupt change in body weight regulation because tissues that are important for energy homeostasis are partially or completely removed.
Typically, these patients can’t control their appetite and within a very short time after surgery they gain weight quickly. Their energy expenditure is also very low. So even if they cut down on calorie intake, they are typically not able to lose weight.
females lost more weight than males with similar exposures to liraglutide, suggesting that body size may not be the only factor.
WeightControl.com Interview with: A/Prof Samantha L Hocking | Associate Professor Diabetes NSW & ACT Sydney School of Medicine (Central Clinical School) Charles Perkins Centre Faculty of Medicine and Health President National Association of Clinical Obesity Services
WeightControl.com: What is the background for this study?
Response: Numerous studies have shown that the mean response to a weight loss intervention hides significant individual variation. There are biological and physiological differences between males and females so gender is a potential predictor of weight loss outcomes.
Exercise is optimal for long-term weight control and prevention of type 2 diabetes when compared with low-calorie diet, low-calorie diet & exercise, fasting, commercial weight loss program, and diet pills.
WeightControl.com Interview with: Dr. Keyi Si, PhD Department of Nutrition Harvard T.H. Chan School of Public Health
WeightControl.com: What is the background for this study?
Response: Weight control is one of the primary and effective strategies for the prevention and management of obesity and related chronic diseases. However, long-term weight change and risks of developing type 2 diabetes following various weight loss strategies are understudied, especially among originally lean individuals.
We know that many people living with obesity do not want to attend health care appointments after a perceived “failure” of a weight loss intervention
WeightControl.com Interview with: Prof Jennifer Logue Associate Dean (Research) Faculty of Health and Medicine Lancaster University Deputy Clinical Director | NIHR CRN North West Coast Professor of Metabolic Medicine | Lancaster University Hon Consultant in Metabolic Medicine Blackpool Victoria Hospital
WeightControl.com: What is the background for this study?
Response: Currently, many providers may offer more intensive therapies to every patient as they don’t believe behavioural programmes are effective, when they are for many people. Other providers leave patients struggling in a behavioural programme and they will disengage, reinforcing self-stigma.
The main messages are that the liver can directly control the most complex part of the brain.
WeightControl.com Interview with: Tamas L. Horvath, DVM, PhD Jean and David W. Wallace Professor of Comparative Medicine Chair, Department of Comparative Medicine Founding Director, Yale Program in Integrative Cell Signaling & Neurobiology of Metabolism Professor of Neuroscience and Ob/Gyn & Reproductive Sciences Yale University School of Medicine
WeightControl.comWhat is the background for this study? What are the main findings?
Response: We knew from earlier work that this very specific lipid species we studied (lysophospholipids) have an impact on how the most complex part of our brain, the cerebral cortex, functions. What is knew here is that we show that the level of these lipids fluctuate in association with the level of hunger of animals and that this fluctuation of these liver-derived lipid molecules are governed by neurons that control hunger and are in an ancient part of the brain (hypothalamus).
Individuals who are high on food cue responsiveness typically have uncontrolled eating and ruminate (think) about food a lot of the time
WeightControl.com Interview with:
Dr. Kerri N. Boutelle, Ph.D Department of Pediatrics Herbert Wertheim School of Public Health and Human Longevity Science, Department of Psychiatry University of California, San Diego, La Jolla, California
WeightControl.com: What is the background for this study? What are the main findings?
Response: Behavioral weight loss, which includes nutrition and physical activity education and behavior therapy techniques (also called a lifestyle intervention), is not effective for all adults with overweight and obesity and of those who lose weight, the majority regain the weight back. This suggests that there are unaddressed underlying mechanisms that impact the effectiveness of these interventions.
We developed a novel weight loss model based on appetitive traits, called regulation of cues (roc), that targets improving responsiveness to hunger and satiety cues and decreasing responsiveness to food cues. This is different than behavioral weight loss as it targets these internal control mechanisms while behavioral weight loss targets external control mechanisms.
After bariatric surgery there is a rapid weight loss that may impair an adequate weight gain during pregnancy and may also be associated with nutritional deficiencies
WeightControl.com Interview with: Dr Ana Carreira and Dr Bárbara Araújo Department of Endocrinology and Metabolism Centro Hospitalar e Universitário de Coimbra Coimbra, Portuga
WeightControl.com: What is the background for this study?
Response: Bariatric surgery is increasingly common in women of reproductive age and reduces the risk of obesity-related comorbidities in pregnancy. However, women after bariatric surgery have an increased risk of having a baby who is underweight (small for gestational age, SGA). A shorter bariatric surgery-to-conception interval (BSCI) has been one of the factors associated with a higher risk of SGA neonates, and, as a result, women are generally advised to wait at least 12 months after bariatric surgery before trying to conceive. However, the optimal bariatric surgery-to-conception interval is yet to be determined, and current recommendation differ among scientific societies, with some advocating a minimum of 12months and others 18 or 24 months.