WeightControl.com Interview with:
Eric C. Nemec PharmD MEHP BCPS
Director of Research and Assessment
Associate Professor
Master of Physician Assistant Program
Sacred Heart University
Office location: 4 Hospital Plaza, Tandet Center, Stamford, CT 06902
WeightControl.com: What is the background for this study?
Response: When we started this project, we knew that glucagon-like peptide-1 receptor agonists (GLP-1RAs) were highly effective for weight loss; however, there was limited evidence regarding the sustainability of that weight loss after treatment cessation.
Our study systematically reviewed and meta-analyzed randomized controlled trials to determine the extent of weight regain after GLP-1RA discontinuation. The key finding was that significant weight is regained after stopping therapy, and this regain was proportional to the amount initially lost.