Penn Researchers Identify Brain Circuits That Increase Risk for Obesity

These findings underscore that some individual’s brains can be fundamentally different in regions that increase the risk for obesity.

WeightControl.com Interview with:

Casey H. Halpern, MD
Division Head, Functional and Stereotactic Neurosurgery
Associate Professor of Neurosurgery
University of Pennsylvania

WeightControl.com:  What is the background for this study? 

Response: The dorsolateral hippocampus (dlHPC) is located in the region of the brain that processes memory, and the lateral hypothalamus (LH) is in the region of the brain that is responsible for keeping the body in a stable state, called homeostasis. Previous research has found an association with loss of function in the human hippocampus in individuals with obesity and related disordered eating, like BED. However, outside of imaging techniques such as magnetic resonance imaging (MRI), the role of the hippocampus has been difficult to study in humans with obesity and related eating disorders.

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