Obesity Drugs: More Protein Needed to Offset Muscle Loss

Multiple studies now report that the amounts of skeletal muscle loss with these new powerful weight loss agents is quite large, up to 40% of weight loss.

WeightControl.com Interview with:

Steven B. Heymsfield, M.D.
Professor and Director of the Body Composition-Metabolism Laboratory
Pennington Biomedical Research Center of the
Louisiana State University System in Baton Rouge

WeightControl.com:  What is the background for this study? 

Response: The recent introduction of glucagon receptor-1 agonists for weight control opens a new era in obesity pharmacotherapy. The greater weight loss with the new drugs is revealing a long-standing recognition that negative energy balance is accompanied by not only decrements in body fat, but also lean protein-containing tissues such as liver, kidney, and skeletal muscle.

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Pennington Study Demonstrates Long-Term Weight Loss Efficacy of Semaglutide

The long term data is reassuring.  We now have more evidence for semaglutide weight loss efficacy in older, sicker individuals.

WeightControl.com Interview with:
Donna H. Ryan, MD
Professor Emerita
Pennington Biomedical Research Center
New Orleans, LA 70130

WeightControl.com:  What is the background for this study? 

Response: This is the first of the sub-papers to the landmark SELECT study.  It has been peer review and published in a top-line journal.  While the primary outcome was the observation of 20% reduction in MI, stroke and CV death this new paper looks only at weight. 


WeightControl.com:   What are the main findings?