Weight Control at WeightControl.com

Sex Differences in Fat Metabolism after Fasting

WeightControl.com Interview with:
Stéphanie Abo, PhD
Applied Mathematics
University of Waterloo

WeightControl.com: What is the background for this study?

Response: Our study examines how men and women process food differently, particularly how each sex responds to a high-carb versus a high-fat diet. Obesity and related conditions, like type 2 diabetes, are major global issues, and nutrition plays a key role in managing these conditions.

Men and women metabolize fats and carbohydrates differently, especially during fasting and exercise. Using a mathematical model and computer simulations, we investigated sex differences in the processing of glucose and fat and identified candidate pathways behind these sex-specific differences. This research can help improve personalized nutrition and diet strategies for both men and women.

Fasting Mimicking Diet: Five Days Per Month Demonstrated Improved Biomarkers for Aging and Disease Risk

The fasting mimicking diet is a five-day long meal program specifically designed to mimic the beneficial effects of fasting while allowing a person to eat and providing the necessary nutrients

WeightControl.com Interview with:
Valter D. Longo PhD
Edna M. Jones Professor of Gerontology and Biological Sciences
Director, Longevity Institute, Leonard Davis School of Gerontology
University of Southern California, Los Angeles, CA
AIRC Institute of Molecular Oncology
Italian Foundation for Cancer Research Institute of Molecular Oncolog
Milan, Italy

Sebastian Brandhorst PhD
Associate Professor Of Gerontology Co-Director
Aging Murine Phenotyping Core
University of Southern California, Health Sciences

WeightControl.com: What is the background for this study?

Response: In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. We previously demonstrated that study participants who consumed the FMD for 5 consecutive days per month for 3 months, but otherwise ate their regular diet had reduced body weight, trunk and total body fat, blood pressure, and a favorable safety profile.

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Intermittent Fasting Without Counting Calories for Weight Loss

We found that participants who engaged in time-restricted eating ate 425 fewer calories per day than the control group and lost about 10 more pounds than the control group after one year

WeightControl.com Interview with:
Krista Varady, PhD
Professor, Kinesiology and Nutrition
University of Illinois, Chicago

WeightControl.com: What is the background for this study?

Response: Obesity is a major health issue. Many traditional weight loss diets involve counting calories, which can be cumbersome and difficult to do well. Time-restricted eating, without calorie counting, has become a popular weight loss strategy because it is simple to do. Whether it’s effective in producing weight loss, especially beyond the short term, is unclear.

Lean Individuals Who Intentionally Lose Weight May Risk Diabetes and Inceased Weight Gain

Exercise is optimal for long-term weight control and prevention of type 2 diabetes when compared with low-calorie diet, low-calorie diet & exercise, fasting, commercial weight loss program, and diet pills.

WeightControl.com Interview with:
Dr. Keyi Si, PhD
Department of Nutrition
Harvard T.H. Chan School of Public Health

WeightControl.com: What is the background for this study?

Response: Weight control is one of the primary and effective strategies for the prevention and management of obesity and related chronic diseases. However, long-term weight change and risks of developing type 2 diabetes following various weight loss strategies are understudied, especially among originally lean individuals.

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Time Restricted Eating Reduced Glucose Levels Study of Type 2 Diabetes

For our study, the time window in which participants were allowed to eat was delibarately set to daytime, with the last meal being ingested at 6 PM the latest. We did this so that the time-window fits in the natural, internal day-night rhythm of humans.

WeightControl.com Interview with:
Charlotte Andriessen
Department of Nutrition and Movement Sciences
Maastricht University

WeightControl.com: What is the background for this study? What are the main findings?

Response: In our modern 24h society, most people spread their food intake over at least 14 hours per day. As such, they lack a pronounced fasting state during the night and energy stores are hardly being depleted. Here, we wanted to re-store this pronounced overnight fast in people with type 2 diabetes, by limiting their habitual food intake to a 10-hour daily time window (time restricted eating, TRE) for a period of 3 weeks.

We hypothesized that the utilization of energy stores during the night would increase the need to re-fuel these stores with the first meal of the day, and would therefore result in a better energy uptake via the hormone insulin; i.e. would result in better insulin sensitivity. Although we did not find insulin sensitivity to be increased with TRE, we did find that fasting- and 24h glucose levels were decreased as compared to our control condition, in which participants spread their habitual food intake over at least 14 hours per day. Moreover, our volunteers spent more time in the normal glucose range, whereas the time restricted eating regime did not increase the time spent in hypoglyceamia.

NEJM: Time-Restricted Eating in Weight Loss

Time-restricted eating combined with calorie restriction offer a viable and sustainable approach for person who wants to lose weight.

WeightControl.com Interview with:
Huijie Zhang M.D. & Ph.D
Professor and Chief Physician
Deputy Director of Department of Endocrinology and Metabolism
Nafang Hospital of Southern Medical University
Guangzhou, China

WeightControl.com: What is the background for this study? What are the main findings?

Response: Time-restricted eating is one of the most popular intermittent fasting regimens involving a specific eating period within a 24-hour cycle. Time-restricted eating regimen has gained attention because it reduces weight and enhances adherence. The long-term efficacy and safety of time-restricted eating for weight loss are not clear.

In this randomized clinical trial, among patients with obesity, a regimen of time-restricted eating was not more beneficial with regard to reduction in body weight, body fat, or metabolic risk factors than daily calorie restriction.

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