WeightControl.com: What should readers take away from your report?
Response: Gender differences within pharmaceutical trials may be explained by drug pharmacokinetics. Physiological variations between males and females often result in differences in the way drugs are absorbed, handled, distributed and excreted within the body. Another possible explanation is that females are lighter than males and when the drug doses are the same, this could result in females receiving higher doses in relation to their body weight and therefore having a greater response to the drug.
However, females lost more weight than males with similar exposures to liraglutide, suggesting that body size may not be the only factor.
WeightControl.com: What recommendations do you have for future research as a result of this work?
Response: It would be beneficial to obtain data from authors of pharmaceutical clinical trials that did not report weight loss for males and females. It may also be worthwhile examining gender differences in response to anti-obesity medications currently in development. There is a need for future pharmaceutical clinical trials to stratify weight loss outcomes by gender.
Disclosures:
A/Prof. Samantha Hocking:
Investigator on weight loss clinical trials with Novo Nordisk
Serves on advisory boards for Novo Nordisk
Honoraria from Novo Nordisk for presentations on the management of obesity
Research support from Novo Nordisk
A/Prof. Tania Markovic:
Served on advisory board for Novo Nordisk
Citation:
International Congress on Obesity, Melbourne – Abstract O78
O78 | Gender differences in weight loss using anti-obesity Medications
A. K. Susanto; S. Hocking; T. Markovic; T. Gill
Medicine and Health, The University of Sydney, Sydney,
New South Wales, Australia
https://drive.google.com/file/d/1ocXVuWKcxmoTI3y3TbUJXbQ3kI-GrHr9/view
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Last Updated on October 20, 2022 by weightcontrol