WeightControl.com: What should readers take away from your report?
Response: One of the most important findings from these studies is that even very severe heart failure can be reversed. However, heart failure that is resulting from myocardial damage, from coronary artery disease and myocardial infarction for example, is likely not easy to reverse. The bottom line is that hearts really need to be able to metabolize fatty acids. However, pyruvate entry into the mitochondria is essential for maintaining heart function.
WeightControl.com: What recommendations do you have for future research as a result of this work?
Response: As mentioned above, it should be tested whether high fat or ketogenic diets can improve heart failure from typical etiologies such as myocardial infarction and chronic hypertension. Of course, it will also be important to know whether these dietary interventions improve cardiac remodeling and function in humans. In fact, there are a number of ongoing clinical trials both nationally and internationally testing ketogenic diets and ketone supplements in various forms of heart failure.
McCommis, K.S., Kovacs, A., Weinheimer, C.J. et al. Nutritional modulation of heart failure in mitochondrial pyruvate carrier–deficient mice. Nat Metab (2020). https://doi.org/10.1038/s42255-020-00296-1
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